The second major route of AH into the brain is through its production by a yeast called Candida albicans. Research over the last several decades has shown that alcoholics tend to rapidly convert alcohol to AH, but then convert AH to acetate very slowly, thus giving AH a chance to work its mischief in the body.1 And depending on a person's genetics, nutritional status, and exposure to other chemicals such as formaldehyde, which also utilize aldehyde dehydrogenase for their detoxification, even non-alcoholics may have difficulty rapidly detoxifying AH. However, the conversion of AH to acetate does not always occur quickly or smoothly and therein lies the problem. (Acetate is a form of acetic acid, the acid that makes vinegar sour.) Acetate can then serve as a fuel in cellular energy production. Then another enzyme "aldehyde dehydrogenase" must break the AH down into acetate. An enzyme called "alcohol dehydrogenase" converts alcohol into AH. The first step occurs primarily in the liver, although other organs such as the brain and kidney can also perform this stage of alcohol detoxification to a slight extent. However, this process takes time and occurs in several steps. Once in the body, alcohol is broken down into carbon dioxide and water. These beverages serve as carriers to get ethanol into the drinker's brain, promoting some degree of intoxication. These are alcohol consumption, Candida "the yeast syndrome," exhaust from cars and trucks, and cigarette smoking.Įthanol (more commonly known as alcohol) is the chemical contained in beer, wine, liquor and liqueurs that gets people drunk. There are four main routes that bring acetaldehyde (abbreviated here as "AH") into the human brain. It is a simple substance its chemical formula is CH3CHO yet acetaldehyde insidiously promotes damage to brain structure and function through numerous pathways. Acetaldehyde - A Common and Potent NeurotoxinĪcetaldehyde is hardly a household word in America, yet it is one of the most common neurotoxins in the lives of tens of millions of people.
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